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OJBTM
Online Journal of
Bioinformatics ©
Volume 14 (2):
126-137, 2013
In silico genome analyses
of putative white spot syndrome virus vaccine sites.
S. Jeevan
Amos (MSc), Subhalaxmi Nayak
(MSc), K. Umadevi
(PhD)*
DBT – BIF Programme, Department of Marine Living Resources, Andhra
University, Visakhapatnam – A. P., India.
ABSTRACT
Amos SJ, Nayak
S, Umadevi K., In silico genome analyses of putative
white spot syndrome virus vaccine sites, Onl J Bioinform., 14 (2):
126-137, 2013. White spot syndrome (WSS)
is a
devastating disease in the
shrimp
industry. Subtractive genomics was used to identify putative vaccine sites on
the outer coat of the virus. Of 531 coding
sequences, 128 were non-homologous protein to the virus of which a set of 28
genes were predicted as putative targets using functional assignment support
vector machine. Sub-cellular localization
prediction showed that 11 of those proteins were located on the outer membrane
and could possibly be used as vaccine receptor candidates. The targets must be experimentally validated in vivo for their role in viral survival
and virulence.
Key Words:White spot
syndrome, shrimp, subtractive
genomics, virus vaccine.
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