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Online Journal of Bioinformatics ©
Volume 14 (2): 126-137, 2013
In silico genome analyses of putative white spot syndrome virus vaccine sites.
S. Jeevan Amos (MSc), Subhalaxmi Nayak (MSc), K. Umadevi (PhD)*
DBT – BIF Programme, Department of Marine Living Resources, Andhra University, Visakhapatnam – A. P., India.
Amos SJ, Nayak S, Umadevi K., In silico genome analyses of putative white spot syndrome virus vaccine sites, Onl J Bioinform., 14 (2): 126-137, 2013. White spot syndrome (WSS) is a devastating disease in the shrimp industry. Subtractive genomics was used to identify putative vaccine sites on the outer coat of the virus. Of 531 coding sequences, 128 were non-homologous protein to the virus of which a set of 28 genes were predicted as putative targets using functional assignment support vector machine. Sub-cellular localization prediction showed that 11 of those proteins were located on the outer membrane and could possibly be used as vaccine receptor candidates. The targets must be experimentally validated in vivo for their role in viral survival and virulence.
Key Words:White spot syndrome, shrimp, subtractive genomics, virus vaccine.