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OJBTM
Online Journal of Bioinformatics ©
Volume 10 (1):93-97, 2009
In
silico
identification of small interfering RNA (siRNA) in the
putative genes of White Spot Syndrome virus.
Singh V, Somvanshi P
Bioinformatics
Centre,
ABSTRACT
Singh V, Somvanshi P, In silico
identification of small interfering RNA (siRNA) in the putative genes of White
Spot Syndrome virus. Online J Bioinformatics, 10
(1):93-97, 2009. White
spot syndrome virus (WSSV) is an important shrimp pathogen causing extensive
economic losses worldwide. Currently, no efficient approach is available to
control this virus. An innovative tactic was employed for controlling the virus
with small interfering RNA (siRNA). It is a class of 20-25 bp double-stranded RNA molecules which interferes with the
expression of a specific gene. Nine
significant putative genes encoding the virulence proteins from WSSV were used
for identification of siRNA and their verification was done by in silico
approach. The siRNA might be use for knockdown the WSSV and may also helpful
for designing the live attenuated vaccine for controlling infection in shrimps.
Keywords: White spot syndrome virus, siRNA,
pathogenesis, knockdown, vaccine
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