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Online Journal of Bioinformatics ©
Volume 10 (1):93-97, 2009
In silico identification of small interfering RNA (siRNA) in the putative genes of White Spot Syndrome virus.
Singh V, Somvanshi P
Singh V, Somvanshi P, In silico identification of small interfering RNA (siRNA) in the putative genes of White Spot Syndrome virus. Online J Bioinformatics, 10 (1):93-97, 2009. White spot syndrome virus (WSSV) is an important shrimp pathogen causing extensive economic losses worldwide. Currently, no efficient approach is available to control this virus. An innovative tactic was employed for controlling the virus with small interfering RNA (siRNA). It is a class of 20-25 bp double-stranded RNA molecules which interferes with the expression of a specific gene. Nine significant putative genes encoding the virulence proteins from WSSV were used for identification of siRNA and their verification was done by in silico approach. The siRNA might be use for knockdown the WSSV and may also helpful for designing the live attenuated vaccine for controlling infection in shrimps.
Keywords: White spot syndrome virus, siRNA, pathogenesis, knockdown, vaccine