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OJB©
Online Journal of Bioinformatics©
Volume 5:32-48, 2004.
Wave analysis of
microarray expression as predictor of gene expression in tumors.
Alok Gupta and Shipra Agrawal*
Indian
Institute of Information Technology
ABSTRACT
Gupta A,
Agrawal S., Wave analysis of microarray expression as
predictor of gene expression in tumors. Onl J Bioinform.,
5:32-48,
2004.
Microarray gene expression, analyzed by cluster data algorithms may be used to
characterize phenotypic variables such as tumor type and gene mutational
status. In this study, microarray data from human fibroblasts taken from ten
anatomical sites was transformed to wave data (wave transform). Analysis
showed that the genes responsible for fibroblastic serum response were
regulated in a coordinated manner in tumors which could allow identification of
tumors with specific gene expression signatures. The findings suggest that
classifiers for specific cancer types could be used to predict the progression
behavior of cancers and prognosis.
Key words:
Wavelet transforms,
array expression analysis and human cancer.