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OJBTM
Online Journal of Bioinformatics ©
Volume 16 (1): 8-17, 2015.
Modelling
simulation phylogenetics of leukemia FMS tyrosine
kinase 3 (FLT3).
Peddanna Kotha, Jayasimha Rayalu Daddam2*, Venkata
Ramana Sai Gopal Divi3, Subba Rao
Dakinedi4, Muralidhararao
Dowlathabad5
1,3DST-PURSE, Sri Venkateswara
University, Tirupati, A.P. INDIA, 2Department
of Biotechnology, JNTUA, Anantapur, A.P. INDIA, 4Department of Chemical Engineering, JNTUA College of Engeneering, Anantapur, A.P.
INDIA, 5Department of
Biotechnology, Sri Krishnadevaraya University, Anantapur, A.P. INDIA.
ABSTRACT
Kotha P, Rayalu Daddam J, Sai Gopal Divi VR, Dakinedi SR, Dowlathabad M., Modelling simulation phylogenetics
of leukemia FMS tyrosine kinase 3 (FLT3). Onl J Vet
Res., 16 (1): 8-17,
2015. Acute Mylenoid
Leukemia, a blood and bone marrow cancer is characterized by abnormal proliferation
of white blood cells. Genes regulating heamatopoiesis
can alter susceptibility to Leukemia. FMS like-tyrosine kinase-3 (FLT3) plays a
key role in cell proliferation and differentiation. A three dimensional model
of FLT3 was generated using 1RJB (Chain A: Crystal structure of Juxta membrane
domain of FLT3), as a template with Modeller7v7. With the aid of molecular
mechanics and dynamic methods a model was generated checked by Procheck and 3D graph. After energy minimization, the 3D
structure of FLT3 was compared with a template, and 21 genes coding for FLT3
and their locus regions were identified. Multiple alignment and phylogenetic
analysis showed that FLT3 family proteins had 4 branches. Functional mutations
within FLT3 domain region were identified.
KEY WORDS:
Acute mylenoid Leukemia, FLT3, Modelling, Molecular
Dynamics, Phylogenetic analysis.
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