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Online Journal of Bioinformatics ©
Volume 15 (2): 191-197, 2014.
Structure of tumor suppressor gene protein (PTEN) by homology modelling.
Babita Rathore1, Madhvi Shakya2
1Department(s) of Bioinformatics and 2Mathematics, MANIT, Bhopal- 462051, India
Rathore B, Shakya M., Structure of tumor suppressor gene protein (PTEN) by homology modelling, Onl J Bioinform., 15 (2): 191-197, 2014. PTEN (Phosphatase and Tensin homolog deleted on chromosome 10), a tumor suppressor gene mutates in human tumors including melanoma. PTEN regulates cell growth, apoptosis and proliferation. De-regulation of this protein is also involved in several other diseases. Homology modeling was done with Protein Structure Prediction Server (PS2), energy minimized with GROMACS, and assessed by PROCHECK and WHATCHECK. A 3D structure of PTEN constructed through homology modelling is shown.
Keywords: Melanoma, PTEN, Homology Modelling.