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OJB®
Online
Journal of Bioinformatics ©
Volume
7 (2): 85-89, 2006.
Dowlathabad MR1, Venkata RD2, Rallapalli
R2
1Department of
Biotechnology, Bioinformatics Laboratory and 2Department of
Microbiology,
ABSTRACT
Dowlathabad MR, Venkata
RD, Rallapalli R., In silico Homology modeling and
Structure assessment of Holo (Acyl Carrier Protein) synthetase from Treponema pallidum, Onl
J Bioinform., 10 (2) :85 - 89, 2006. Computational data provides new
opportunities for finding optimal targets among previously unexplored cellular
functions based on an understanding of their related biological processes in
bacterial pathogens and their hosts. The experimental structure for Holo Acyl Carrier Protein synthetase of Treponema pallidum is still
unknown for the reason that Treponema pallidum could not be grown in vitro
conditions. A computational 3D model and structure assessment for ACP synthetase of Treponema pallidum is described with the aim
of designing appropriate inhibitor(s) against acp synthetase of
Treponema pallidum.
Key words: Troponema pallidum, Homology modeling, Holo (Acyl carrier protein) Synthetase