©1996-2019 All Rights Reserved. Online Journal of Bioinformatics . You may not store these pages in any form except for your own personal use. All other usage or distribute on is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJB publications. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.
Online Journal of Bioinformatics ©
Volume 12(1):139-148, 2011
Bio-computational interaction analysis of acetylcholinesterase(AChE) Toxin C
from Dendroaspis Polylepis with human hippocampal AChE
Tanmaya Kumar Sahu1* and Mahesh Chandra Patra2
1Indian Agricultural Statistics Research Institute, New Delhi and 2PG Department of Bioinformatics, Orissa University of Agriculture and Technology, Bhubaneswar, Orissa, India
Sahu TK, Patra MC., Bio-computational interaction analysis of acetylcholinesterase (AChE) Toxin C from Dendroaspis polylepis with human AChE, Onl J Bioinform., 12(1):139-148, 2011. A computational interaction model of a peptide acetyl-cholinesterase toxin C (AChETC) from the venom of Dendroaspis Polylepis (Black Mamba) with human hippocampal AChE is described. The 3D structures of AChE and AChETC were modeled by the program MODELLER interfaced with Discovery Studio 2.5. Protein-protein docking was performed by the GRAMM-X web server. The key residues Arg27, Pro30 and Pro31 of AChETC were found to participate in AChE inhibition by forming hydrogen bonds and several other electrostatic and hydrophobic interactions with AChE.
Key Words: Alzheimer’s, Acetylcholinesterase, Acetylcholinesterase toxin C, Docking, Homology Modeling