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OJBTM

 Online Journal of Bioinformatics 

Volume 12(2):243-254, 2011


In-silico inhibition of telomerase associated proteins.

 

Jyoti P (MSc), Vidyarthi AS (PhD), Shankaracharya* (MSc)

 

Department of Biotechnology, Birla Institute of Technology, Mesra, Ranchi, India.

 

ABSTRACT

 

Jyoti P, Vidyarthi AS, Shankaracharya M., In-silico inhibition of telomerase associated proteins, Onl J Bioinform, 12(2):243-254, 2011. KIP, p23 and NHP2 protein are associated with telomerase RNA subunits TERC and TERT. Over-expression of these proteins leads to carcinogenicity in humans. Prediction and validation of protein tertiary structures, and docking and ADME analysis was performed with drug like molecules. Results suggested that zinc_04794736, 45323900 and 04543942 from NCBI which bind with p23, NHP2 and KIP protein respectively, could provide a base for a cancer drug. Quinine sulphate may inhibit KIP and NHP2 and tumor proliferation.

 

Keywords: Telomere, Telomerase, Telomerase associated proteins, homology modeling.


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