1996-2019. All Rights Reserved. Online Journal of Bioinformatics . You may not store these pages in any form except for your own personal use. All other usage or distribute on is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the  before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJB publications. This article may be copied once but may not be, reproduced or  re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


 Online Journal of Bioinformatics 

Volume 12(2):371-378, 2011

In silico T cell antigens from proteome of H1N2 swine influenza A virus.


Sitansu Kumar Verma, Shivam Pratap Singh Yadav and Ajay Kumar.


Department of Biotechnology, Institute of Biomedical Education and Research, Mangalayatan University,   Aligarh (U.P), India




 Verma SK, Singh Yadav SK, Kumar A., In silico T cell antigenic determinants from proteome of H1N2 swine influenza A virus, Online J Bioinformatics, 12(2):371-379, 2011. In silico peptides for development of vaccines against swine influenza H1N2 are described.  Propred and Propred I were used to predict T cell epitopes from hemagglutinin, neuraminidase, polymerase, polymerasebasic 1, polymerase 2, matrix protein 1, matrix protein 2, nonstructural protein 1,  nonstructural protein 2, and nucleocapsid protein of influenza virus (A/Sw/It/116114/2010) (H1N2). A 4% threshold was used to select high binding affinity peptides. A total of 21 epitopes were predicted for HLA class I and 20 epitopes for HLA class II molecules. These T cell epitopes were top scoring peptides and bound with the maximum number of HLA alleles.


Keywords: T cell epitope, Propred, Influenza A virus (H1N2), Human Leukocyte antigen.