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OJBTM
Online Journal of Bioinformatics ©
Volume 12(2):371-378, 2011
In silico T cell antigens from proteome of H1N2
swine influenza A virus.
Sitansu Kumar Verma, Shivam Pratap
Singh Yadav and Ajay Kumar.
Department of Biotechnology, Institute of
Biomedical Education and Research, Mangalayatan
University, Aligarh (U.P), India
ABSTRACT
Verma SK, Singh Yadav SK, Kumar
A., In silico T cell antigenic determinants from proteome of H1N2 swine
influenza A virus, Online J Bioinformatics, 12(2):371-379, 2011. In silico peptides for development of vaccines
against swine influenza H1N2 are described. Propred
and Propred I were used to predict T cell epitopes
from hemagglutinin, neuraminidase, polymerase, polymerasebasic
1, polymerase 2, matrix protein 1, matrix protein 2, nonstructural protein
1, nonstructural protein 2, and nucleocapsid
protein of influenza virus (A/Sw/It/116114/2010)
(H1N2). A 4% threshold was used to select high binding affinity peptides. A
total of 21 epitopes were predicted for HLA class I and 20 epitopes for HLA
class II molecules. These T cell epitopes were top scoring peptides and bound
with the maximum number of HLA alleles.
Keywords: T cell epitope, Propred,
Influenza A virus (H1N2), Human Leukocyte antigen.
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