©1996-2019 All
Rights Reserved.
Online Journal of Bioinformatics . You may not store
these pages in any form except for your own personal use. All other usage or
distribution is illegal under international copyright treaties. Permission to
use any of these pages in any other way besides the
before mentioned must be gained in writing from the publisher. This
article is exclusively copyrighted in its entirety to OJB publications. This
article may be copied once but may not be, reproduced or
re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher
Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page
you must link directly to this page only here rather than put up your own page.
OJB®
Online
Journal of Bioinformatics ©
Volume 7
(1) : 35-45, 2006.
Comparative structure analysis of chorismate synthase.
Marla S , Yalamanchili HK, Gelli P,
Singh HK, Praveen G, Ghatta G, Srikanth S, Goutham K.
Biotechnology and Bioinformatics Department,
JayaPrakash University of Information technology, Solan, H.P.173215, India.
ABSTRACT
Marla S , Yalamanchili
HK, Gelli P, Singh HK, Praveen G, Ghatta G, Srikanth S, Goutham K,
Comparative structure analysis of Chorismate synthase, Onl J Bioinform., 7 (1) : 35 - 45, 2006.
This work compares chorismate synthase structure
in various microorganisms. The enzyme is essential in the shikomate pathway in
bacteria, fungi and plants, but not in mammals. It is a useful target for drug
design inhibiting functional pathways with chemotherapeutic effects.
Binding of essential co-factors Flavin mononucleotide (FMN) and 5-enolpyruvil
shikomate-3-phosphate(EPSP) affects its activity. The
results of FMN structure analysis and in various microorganisms are
presented. Comparative modeling and extent of
structure similarities between H. pyroli and P. rumnicola
were performed using alpha and beta fold patterns, FMN binding and main chain
configuration residues. Active sites for binding of FMN
were detected. Phylogeny analysis was evaluated in various
microorganisms.
Key words:
Chorismate synthase, flavin
mononucleotide, Binding sites, Helicobacter pyroli, Prevotella rumnicola.