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Onl J Bioinform©


Established 1995

ISSN  1443-2250

 

Volume 25 (1) : 60-78, 2024.

Spot recognition for single nucleotide polymorphism microarrays.

 

Huang CY1, Liu L2

 

1Center for Pharmacogenomics and Complex Disease Research, University of Medicine & Dentistry of New Jersey, Newark, NJ 07101, USA 2Department of Applied Mathematics, Chung Yuan Christian University, Chung-Li, Taiwan

 

ABSTRACT

 

Huang CY, Liu L, Spot recognition for single nucleotide polymorphism microarrays.. Onl J Bioinform., 25 (1) : 60-78, 2024. We describe automated microarray spot intensity by circular template image bipartition and mesh algorithms. Our method automatically locates spots on an assay plate and reports foreground and background Intensity and status which can be applied onto plate, slide, or other container for gene-expression and single nucleotide polymorphism genotyping image. We found 99.98% accuracy for spot detection and total processing time generated millions of genotyping assays 12h.

 

Keywords: microarray, image, SNP, genotype, spot, high throughput.

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