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Online Journal of Bioinformatics

Volume 14(2):207-212, 2013

Selection pressure analysis of African swine fever virus attachment protein p12 gene.


You-Fang Chen1, Youhua Chen2*


1School of Software, Harbin Normal University, Heilongjiang Province, China 2Department of Renewable Resources, University of Alberta, Edmonton, T6G 2H1, Canada *Email:




Chen YF, Chen Y., Selection pressure analysis of African swine fever virus attachment protein p12 gene, Onl J Bioinform., 14(2):207-212, 2013. A study to determine whether there is positive selection of the attachment protein p12 gene of African swine fever virus (ASFV) is described. The functional divergence among the sequences was very low as shown by nucleotide diversity. It was found that the gene is most likely undergoing purifying selection instead of positive selection. Through the likelihood-ratio test of nested models, one positively selected site 47D (in the template M84183) was identified by Bayes Empirical Bayes analysis but this was not statistically significant. In conclusion, adaptive evolution is unlikely for this structural gene.


KEYWORDS: natural selection, structural protein, adaptive evolution, Bayesian probability