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Selection pressure
analysis of African swine fever virus attachment protein p12 gene.
You-Fang Chen1,
Youhua Chen2*
1School of Software, Harbin Normal
University, Heilongjiang Province, China 2Department of Renewable
Resources, University of Alberta, Edmonton, T6G 2H1, Canada *Email: youhuach@gmail.com
ABSTRACT
Chen
YF, Chen Y., Selection pressure analysis of African swine fever virus
attachment protein p12 gene, Onl J Bioinform., 14(2):207-212,
2013. A study to determine whether there is positive selection of
the attachment protein p12 gene of African swine fever virus (ASFV) is
described. The functional divergence among the sequences was very low as shown
by nucleotide diversity. It was found that the gene is most likely undergoing
purifying selection instead of positive selection. Through the likelihood-ratio
test of nested models, one positively selected site 47D (in the template
M84183) was identified by Bayes Empirical Bayes analysis but this was not
statistically significant. In
conclusion, adaptive evolution is unlikely for this structural gene.
KEYWORDS: natural selection, structural
protein, adaptive evolution, Bayesian probability
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