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OJBTM
Online Journal of Bioinformatics ©
Volume
13 (1):103-119, 2012
EST secretome analysis of Radopholus
similis nematode.
Sangeetha K.1, Rosana O. Babu1*, Santhosh J. Eapen2
1Bioinformatics
Center, 2 Division of crop protection, Indian Institute of Spices
Research, Calicut, Kerala, India.
ABSTRACT
Sangeetha K, Babu
RO, Eapen SJ., EST secretome
analysis of Radopholus similis
nematode. Onl J Bioinform., 13 (1):103-119, 2012. Plant parasitic nematodes excrete or secrete (ES)
various types of molecules in host plants. The secretome
of Radopholus similis
could identify drug targets and biomarkers for diagnostics or nematode
survival factors. Patterns of gene annotation and functional diversity of
excretory/secretory proteins of burrowing nematode (R. similis)
were determined. Two hundred fourteen secretory proteins of R similis were
identified. Forty six percent of gene ontology terms were associated with
biological processes, 38% with molecular function and 16% with cellular
components. InterProScan revealed EGF and IGFBP like
domains. The role of hypothetical proteins involved in signaling, metabolic and
degradative pathways and those preserved for R. similis
species are described.
Keywords: Radopholus similis, secretome
analysis, Expressed Sequence Tags
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