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Online Journal of Bioinformatics©
Volume 22 (3): 230-257, 2021.
MicroRNAs in brain and genes associated with amyotrophic lateral sclerosis.
Santosh P. Shinde, Neelima Arora and Utpal Bhadra.
Functional Genomics and Gene Silencing Group, Centre for Cellular and Molecular Biology, Hyderabad-500007, India
Shinde SP, Arora N, Bhadra U., MicroRNAs in brain and genes associated with amyotrophic lateral sclerosis, Onl J Bioinform., 22 (3): 230-257, 2021. Amyotrophic Lateral Sclerosis (ALS) is a rare neurological disease affecting mainly motor neurons which can lead to paralysis and death in extreme cases. We predicted target sites for microRNAs in brain and CNS for 35 ALS associated genes. MicroRNA target sites were classified by position and location for gene silencing verificed by TargetScan and PicTar for sites in 3´ UTR. Target sites (1456) for mRNA’s repression of gene expression were identified with miRanda algorithms. Most sites were found in 5´ UTR and CDS region with 11 common to all (3) algorithms.
Key-words: MicroRNA, CNS, genes, Sclerosis.
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