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OJBTM
Online
Journal of Bioinformatics ©
Volume
13(2):285-313,
2012.
Riboswitch as a target for Streptococcus pneumoniae
Somdutt
Mujwar* and Kamal R. Pardasani
Department of Mathematics, MANIT
Bhopal, India
Mujwar S, Pardasani KR., Riboswitch as a
target for Streptococcus pneumonia.
Online J Bioinform., 13(2):285-313, 2012. Riboswitch
is part of mRNA present in the 5’ un-translated
region (UTR) that controls gene expression by
initiation or termination of translation by binding a specific ligand to the
binding site present in the riboswitch aptamer. Identification of riboswitches as a target for
Streptococcus pneumoniae is
described. ZINC19325791, ZINC19362650 and ZINC08652230 inhibited S.
pneumoniae bacterial riboswitch SPB1 whereas ZINC01584497, ZINC03947435,
ZINC13597738, ZINC01729525 and ZINC01871223 inhibited riboswitch SPR1. The framework
might be used to predict riboswitches and design inhibitors for infectious
disorders.
Key words – Riboswitch, Ligand, Pneumonia,
Drug-design, Inhibitor-design etc.
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