©1996-2019. All
Rights Reserved. Online Journal of Bioinformatics. You
may not store these pages in any form except for your own personal use. All
other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the
before mentioned must be gained in writing from the publisher. This article
is exclusively copyrighted in its entirety to OJIM publications. This article
may be copied once but may not be, reproduced or re-transmitted without the
express permission of the editors. Linking: To link to this page or any pages
linking to this page you must link directly to this page only here rather than
put up your own page.
OJBtm
Online Journal of Bioinformatics©
Established 1995
A theoretical approach
to test possible interaction between
DNA and in
silico platelet P2Y1 receptor.
Arnab Mukherjee.
Indian Institute of Technology Madras, India.
ABSTRACT
Mukherjee A., A theoretical
approach to test
possible interaction between DNA
and in silico platelet P2Y1 receptor, Onl
J Bioinform., 19(2):208-213, 2018. Purinergic
receptors are proteins that respond to sensitization by purine nucleotides to induce signal
transduction pathways. The receptors are classified as ligand-gated ion
channels (P2X type) and G-Protein Coupled Receptors (P2Y type). This work
focuses on a purino receptor that is expressed
greatly on the platelet surface as a high affinity ADP receptor to induce
platelet aggregation. The receptor was
analyzed in silico to determine if the P2Y1 receptor (which evinces a remarkable affinity
for ADP) would respond to DNA as well. Although the
receptor does not strictly fall
into any known family of proteins complexing with DNA theoretical approaches
showed that the receptor may be a suitable candidate for
protein-DNA interaction.
KEYWORDS
: platelets,
purinergic receptors, P2Y1, DNA binding proteins, ADP, docking.
FULL-TEXT(SUBSCRIBE
OR PURCHASE TITLE $25USD)