MAIN


 

1996-2019. All Rights Reserved. Online Journal of Bioinformatics. You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJIM publications. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors. Linking: To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


 OJBtm
Online Journal of Bioinformatics

Established 1995

ISSN  1443-2250


Volume 19(2):208-213, 2018.


 

A theoretical approach to test possible interaction between DNA and in silico platelet P2Y1 receptor.

 

Arnab Mukherjee.

 

Indian Institute of Technology Madras, India.

 

ABSTRACT

 

Mukherjee A., A theoretical approach to test possible interaction between DNA and in silico platelet P2Y1 receptor, Onl J Bioinform., 19(2):208-213, 2018. Purinergic receptors are proteins that respond to sensitization by purine nucleotides to induce signal transduction pathways. The receptors are classified as ligand-gated ion channels (P2X type) and G-Protein Coupled Receptors (P2Y type). This work focuses on a purino receptor that is expressed greatly on the platelet surface as a high affinity ADP receptor to induce platelet aggregation. The receptor was analyzed in silico to determine if the P2Y1 receptor (which evinces a remarkable affinity for ADP) would respond to DNA as well. Although the receptor does not strictly fall into any known family of proteins complexing with DNA theoretical approaches showed that the receptor may be a suitable candidate for protein-DNA interaction.

 

KEYWORDS : platelets, purinergic receptors, P2Y1, DNA binding proteins, ADP, docking.


 

MAIN

 

FULL-TEXT(SUBSCRIBE OR PURCHASE TITLE $25USD)