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OJBTM

Online Journal of Bioinformatics 

Volume 12(1):57-65, 2011


Inhibition of Farnesyl pyrophosphate by allosteric site drug binding

 

Satish kumar(Msc), Jyoti Pathak(Msc), Asha(Msc), Rajib Bandopadhyay(PhD)

 

*,Department of Biotechnology, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India

 

ABSTRACT

 

Kumar S, Pathak J, Asha PJ, Bandopadhyay R, Inhibition of Farnesyl pyrophosphate by allosteric site drug binding, Online J Bioinformatics, 12(1):57-65, 2011 . Hutchinson-Gilford Progeria Syndrome (HGPS) is caused by defective lamin A protein which remains farnesylated after post translational modification. Zoledronate is a potent farnesyl pyrophosphate synthase inhibitor. A total of 45 compounds selected from the Zinc database were docked on protein FPPS through GLIDE and their ADME score were calculated from QikProp.  The analysis suggests that ZINCID13678562, could be used as an alternative to Zoledranate if confirmed by In Vivo pharmacology.

 

Keywords: - Progeria, Zoledronate, GLIDE, ADME, FPPS.


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