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OJBTM

 Online Journal of Bioinformatics © 

Established 1995

ISSN  1443-2250

 

 Volume 24 (2):74-81, 2023.

In silico Streptococcus pneumoniae drug targets by microarray.

 

Wadhwa G1, Setiya K1, Imran Hazra2, Mohan T Madhan1

 

1Apex Bioinformatics Centre, Department of Biotechnology, CGO complex, Lodhi Road, New Delhi, 2Department of Computer Science, Jamia Hamdard, New Delhi.

 

ABSTRACT

 

Wadhwa G, Setiya K, Hazra I, Madhan MT., In silico Streptococcus pneumoniae drug target by microarrays, Onl J Bioinform., 24 (2):74-81, 2023.  Microarray expression data was used to identify genes co-expressed with Streptococcus pneumoniae virulent gene drug targets. Microarray data co-expressed genes with virulence dissimilar to host genome were selected as drug targets. We isolated 50 essential virulent genes without paralogues but sequenced against gut flora yielded 32 genes and against humans left only 13 putative drug targets.  

 

Keywords: clusters, k-mean clustering, drug targets.

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