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OJB
Online Journal of Bioinformaticsâ
Volume
5:1-12, 2004.
Molecular phylogenetics and functional
evolution of major RNA recognition domains
of recently cloned and characterized autoimmune RNA-binding particle.
Suleymanoglu
E.
Institute of
Biochemistry, University of Vienna, Medical Faculty, Vienna Biocenter, Dr.
Bohr-Gasse 9/3, A-1030, Vienna, Austria
SUMMARY
Suleymanoglu E., Molecular phylogenetics
and functional evolution of major RNA recognition
domains of recently cloned and characterized autoimmune RNA-binding particle Onl J Bioinform., 5:1-12, 2004. Heterogeneous nuclear ribonucleoproteins (hnRNPs) are
spliceosomal macromolecular assemblages and thus actively participate in
pre-mRNA metabolism. They are composed of evolutionarily conserved tandemly
repeated motivs, where both RNA-binding and protein-protein recognition occur
to achieve cellular activities. By yet unknown mechanisms these
ribonucleoprotein particles are targeted by autoantibodies and hence play
significant role in variety of human systemic autoimmune diseases. This feature
makes them important prognostic markers in terms of molecular epidemiology and
pathogenesis of autoimmunity. Since ribonucleoprotein (RNP) domain is one of
the most conserved and widespread scaffolds, evolutionary analyses of these
RNA-binding domains can provide further clues on disease-specific epitope
formation. The study presented herein represents a sequence comparison of
RNA-recognition regions of recently cloned and characterized human hnRNP A3
with those of other relevant hnRNP A/B-type proteins. Their implications in
human autoimmunity is particularly emphasized.
KEY WORDS: hnRNP proteins, RNA folding, RNA-protein interactions
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