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OJBTM
Online Journal of Bioinformatics ©
Volume 13(3):375-381, 2012.
A Parkinson’s disease mitochondrial dysfunction pathway
with gene hubs.
Indumathi Kamatchi Balakrishnan
MSc Mphil, Saranya Rangasamy MSc, Mphil, Jeyakumar Natarajan
PhD.
Department
of Bioinformatics, Bharathiar University, Coimbatore,
Tamilnadu, India.
ABSTRACT
Balakrishnan ik, Rangasamy
s, Natarajan j., A Parkinson’s disease mitochondrial dysfunction pathway with
gene hubs, Online J Bioinform., 13(3):375-381, 2012. Mitochondrial dysfunction in Parkinsons disease leads to
increased production of reactive oxygen species detrimental to neurons. A mitochondrial dysfunction pathway map was
constructed from the literature and KEGG database. The resulting network was topologically analyzed for target drug gene
hubs. Results suggest that OXIDATIVE STRESS (most significant), DJ-1, ALPHA SYNUCLEIN AGGREGATION, PI3 and KINASE/AKT SIGNALLING hubs could have
potential therapeutic use.
KEY-WORDS:
Parkinson’s disease, Oxidative stress, Mitochondrial
dysfunction, Topological analysis