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Online Journal of Bioinformatics ©

Volume 13(3):375-381, 2012.

A Parkinsonís disease mitochondrial dysfunction pathway with gene hubs.


IndumathiKamatchi Balakrishnan MSc Mphil, Saranya Rangasamy MSc, Mphil, Jeyakumar NatarajanPhD.


Department of Bioinformatics, Bharathiar University, Coimbatore, Tamilnadu, India.




Balakrishnan ik, Rangasamy s, Natarajan j., A Parkinsonís disease mitochondrial dysfunction pathway with gene hubs, Online J Bioinform., 13(3):375-381, 2012.Mitochondrial dysfunction in Parkinsons disease leads to increased production of reactive oxygen species detrimental to neurons.A mitochondrial dysfunction pathway map was constructed from the literature and KEGG database. The resulting network was topologically analyzed for target drug gene hubs.Results suggest that OXIDATIVE STRESS (most significant), DJ-1, ALPHA SYNUCLEIN AGGREGATION, PI3 and KINASE/AKT SIGNALLING hubs could have potential therapeutic use.


KEY-WORDS: Parkinsonís disease, Oxidative stress, Mitochondrial dysfunction, Topological analysis