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OJBTM

 Online Journal of Bioinformatics © 

Established 1995

ISSN 1443-2250

 

 Volume 24 (2):102-109, 2023


Mitochondrial dysfunction gene hubs in Parkinsonís disease

 

IndumathiKamatchi Balakrishnan MSc Mphil, Saranya Rangasamy MSc Mphil, Jeyakumar NatarajanPhD.

 

Department of Bioinformatics, Bharathiar University, Coimbatore, Tamilnadu, India.

 

ABSTRACT

 

Balakrishnan IK, Rangasamy S, Natarajan J., Mitochondrial dysfunction gene hubs in Parkinsonís disease, Onl J Bioinform., 24 (2): 102-109, 2023. Parkinsonís disease is a chronic progressive neurodegenerative movement disorder. Mitochondrial dysfunction leads to increased production of reactive oxygen species detrimental to neurons. A mitochondrial dysfunction pathway map was constructed from literature and the KEGG database and the resulting network was topologically analyzed for gene nodes (Hubs). OXIDATIVE STRESS, DJ-1, ALPHA SYNUCLEIN AGGREGATION, PI3 KINASE/AKT SIGNALLING nodes were topologically important and identified as significant for potential therapeutic use.

 

KEY-WORDS: Parkinsonís disease, Oxidative stress, Mitochondrial dysfunction, Topological analysis.


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