©2023-2034 All Rights Reserved. Online Journal of Bioinformatics . You
may not store these pages in any form except for your own personal use. All
other usage or distribution is illegal under international copyright treaties.
Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from
the publisher. This article is exclusively copyrighted in its entirety to OJB
publications. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the
editors. This
journal satisfies the refereeing requirements (DEST) for the Higher Education
Research Data Collection (Australia). Linking: To link to this page or any
pages linking to this page you must link directly to this page only here rather
than put up your own page.
OJBTM
Online Journal of Bioinformatics ©
Established
1995
ISSN 1443-2250
Volume 24 (2):102-109, 2023
Mitochondrial dysfunction gene hubs in Parkinson’s disease
Indumathi Kamatchi Balakrishnan
MSc Mphil, Saranya Rangasamy MSc Mphil, Jeyakumar Natarajan
PhD.
Department
of Bioinformatics, Bharathiar University, Coimbatore,
Tamilnadu, India.
ABSTRACT
Balakrishnan IK, Rangasamy S, Natarajan J.,
Mitochondrial dysfunction gene hubs in Parkinson’s disease, Onl
J Bioinform., 24 (2): 102-109, 2023. Parkinson’s
disease is a chronic progressive neurodegenerative movement disorder. Mitochondrial dysfunction leads to increased
production of reactive oxygen species detrimental to neurons. A mitochondrial dysfunction pathway map was
constructed from literature and the KEGG database and the resulting network was topologically analyzed for gene
nodes (Hubs). OXIDATIVE STRESS, DJ-1, ALPHA SYNUCLEIN AGGREGATION, PI3 KINASE/AKT
SIGNALLING nodes were topologically important and identified as significant
for potential therapeutic use.
KEY-WORDS:
Parkinson’s disease, Oxidative stress, Mitochondrial
dysfunction, Topological analysis.
FULL-TEXT
(SUBSCRIBE OR PURCHASE TITLE)