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Journal of Bioinformatics©
Onl J Bioinform©
Established 1995
ISSN 1443-2250
Volume 25 (2) :86-93, 2024.
Jihao Zhou PhD, Yulei
He MS, Ying Yuan, MA MS.
1Clinical
Biostatistics, Pfizer Global Research and Development, La Jolla Laboratories,,
San Diego, California, University of Michigan, Ann Arbor,
Michigan, USA..
Zhou J, He Y,
Yuan Y, One and 2 side nonparametric
Schuirmann’s tests for non-normal pharmacokinetic data,
Onl J Bioinform., 25 (2) :86-93, 2024. Schuirmann’s two one-sided tests (TOST) for
clinical drug-drug interaction assume data normality which may not occur in
practice. We describe statistical tests for non-normal data compared with
nonparametric ones. We used Monte Carlo simulations for non-normal skewed data
and Schuirmann’s TOST and nonparametric tests
compared by empirical power, size and coverage probability. The nonparametric
TOST was based on Wilcoxon signed-rank, Jackknife and
Bootstrap tests. We found that Schuirmann’s TOST is robust
for slightly skewed data, but poor when heavily skewed, whereas Bootstrap yielded
high probability and empirical size.