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OJBTM

Online Journal of Bioinformatics

Established 1995

ISSN  1443-2250

 

Volume 23 (3):251-257, 2022.


In silico interactions of curcumin with human papilloma virus 16 E6 protein cancer

 

Ajay Kumar Singh and Krishna Misra.

 

Centre For Biomedical Magnetic Resonance, SGPGI campus, Lucknow

 

ABSTRACT

 

Singh AK, Misra K., In silico interactions of curcumin with human papilloma virus 16 E6 protein cancer, Onl J Vet Res., 23 (3):251-257, 2022. Curcumin (diferuloyl methane) and its naturally occurring analogs viz. demethoxy, bis-demethoxy and cyclo-curcumin, in rhizomes of Curcuma inhibit proliferation of tumor cells. In silico binding with active sites on HPV E6 protein could be a target to restore tumor suppression of p53 and apoptosis of infected cells. This protein is 158 amino acids long in oral and cervical cancers and may inhibit oral and cervical cancer.

 

KEY WORDS: HPV (Human Papilloma virus), OC