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Online Journal of Bioinformatics©
Volume 10 (2):191-200, 2009.
Identification of active gene modules during pancreatic development.
Gao S, Wang X.
Department of Physics
Gao S, Wang X., Identification of active gene modules during development of the pancreas, Online J Bioinformatics, 10(2):191-200, 2009.. Development of complex organs such as the pancreas relies intricately on dynamically regulated gene networks. By integrating the interactome and transcriptome, four correlated network modules have been identified which are active during mouse pancreatic development, consisting of 56, 60, 120 and 149 of genes, respectively. The four modules are associated with cellular cell cycle, organ development and RNA metabolism. Ontological analysis showed that they may play important roles in pancreatic development. Transcription binding site analysis revealed that the most significantly over-represented binding motifs of genes in modules 1 and 2 are for transcription factors (TFs) pdx1 and sp1, which are known to be most critical in pancreatic development. In contrast, using the gene co-expression clusters alone, did not improve enrichment for GO terms. It is concluded that an integrated approach is needed to investigate the network regulations during development of complex organs such as the pancreas.
Key words: pancreas development, functional modules, interaction network, gene expression.