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Online Journal of Bioinformatics ©
Volume 12(2):395-412, 2011.
In Silico model of Homo sapiens Nectin-4: a novel anticancer drug target.
Dipon Das, Ranjan Preet, Purusottam Mohapatra, Shakti Ranjan Satapathy, Chanakya Nath Kundu.
KIIT School of Biotechnology, KIIT University, Campus-11, Patia, Bhubaneswar, Orissa, India.
Das D, Preet R, Mohapatra P, Satapathy SR, Kundu CN. In Silico model of Homo sapiens Nectin-4: a novel anticancer drug target, Onl J Bioinform., 12(2):395-412, 2011. Nectin 4 is a serum biomarker for cancer as it is highly expressed in cancer cell lines and tumor tissues but not in normal cells. In this study the Nectin-4 protein molecule of Homo sapiens was characterized in silico and its protein structure was predicted using commercial and available online tools. A 3D structure of Nectin-4 was created by homology modeling. Stereochemistry revealed that 99.5% of the residues of the model were in the most allowed regions. Nectin-4 bound to adaptor protein Afadin.
Keywords: Active site prediction, Adhesion molecule, Nectin-4.