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OJBTM
Online Journal of Bioinformatics ©
Volume 13 (1):50-58, 2012
In silico homology model of mutated PTEN protein inducing meningioma
J. Kaur1, A.
Mohan1, S. Kumar1, Pallavi2, A. K. Malakar2*
1BCS Insilico Biology, 2National Bureau of
Fish Genetic Resources, Lucknow U. P., India.
ABSTRACT
Kaur J,
Mohan A, Kumar S, Pallavi A, Malakar
K., In silico homology model of mutated PTEN protein inducing meningioma, Onl J Bioinform, 13 (1):50-58,
2012. PTEN a tumor suppressor gene, encodes protein as a dual specificity protein lipid
phosphatase regulating phosphoinositol-3-kinase/Akt
signal pathway causing cell cycle arrest in G1-phase and apoptosis. A protein
model was generated using MODELLER with 1D5R:A
template. The best model had a DOPE score of -40224.32813 with 88.4% residues
in the most favorable region of a Ramachandran plot. In the generously allowed
and disallowed regions residues were 1.9% and 0.3% respectively. Loop modeling
using MODLOOP analyzed by PROCHECK 3.0 showed 88.4% residues in the most
favorable region and 0.0% in both generously allowed and disallowed regions of
a Ramachandran plot.
Key words: PTEN
protein, Meningioma, Homology Modeling, MODELLER.
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