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Online Journal of Bioinformatics ©
Volume 13 (1):50-58, 2012
In silico homology model of mutated PTEN protein inducing meningioma
J. Kaur1, A. Mohan1, S. Kumar1, Pallavi2, A. K. Malakar2*
1BCS Insilico Biology, 2National Bureau of Fish Genetic Resources, Lucknow U. P., India.
Kaur J, Mohan A, Kumar S, Pallavi A, Malakar K., In silico homology model of mutated PTEN protein inducing meningioma, Onl J Bioinform, 13 (1):50-58, 2012. PTEN a tumor suppressor gene, encodes protein as a dual specificity protein lipid phosphatase regulating phosphoinositol-3-kinase/Akt signal pathway causing cell cycle arrest in G1-phase and apoptosis. A protein model was generated using MODELLER with 1D5R:A template. The best model had a DOPE score of -40224.32813 with 88.4% residues in the most favorable region of a Ramachandran plot. In the generously allowed and disallowed regions residues were 1.9% and 0.3% respectively. Loop modeling using MODLOOP analyzed by PROCHECK 3.0 showed 88.4% residues in the most favorable region and 0.0% in both generously allowed and disallowed regions of a Ramachandran plot.
Key words: PTEN protein, Meningioma, Homology Modeling, MODELLER.