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Online Journal of Bioinformatics ©
Volume 16 (2): 179-187, 2015.
Antibacterial activity and molecular docking in Musa paradisiaca flavonoids.
Jaya Sree1, Shravan Kumar Gunda2
1University College of Science, 2Bioinformatics Division, Osmania University, Hyderabad, Telangana State, India
Sree J, Gunda SK., Antibacterial activity and molecular docking in Musa paradisiaca flavonoids, Onl J Bioinform., 16 (2): 179-187, 2015. We describe anti-bacterial activity and In Silico molecular docking in flavonoids from extracts of Musa paradisiaca (Banana). Extract concentrations were determined by colorimetry against a standard cyaniding curve yielding 71 ug/ml flavonoid in methanol and 63 ug/ml in acetone. Extracts were screened against Pseudomonas marginalis , Pseudomonas aeroginosa, Bacillus cereus, Proteus vulgaris, Staphylococcus aureus and Micrococcus luteus. Results suggested inhibitory activity against bacteria. Molecular docking studies were done with Autodock tools ligands were sketched and energy minimization was performed in Sybyl 6.7, and molecules minimized with Gasteiger-Huckel charges. Amino residues interact with flavonoid inhibitors in the 2C1X binding site which could be responsible for selectivity in flavonoid inhibitors.
Keywords: Musa paradisiaca, antibacterial activity, flavonoids, molecular docking.