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Online Journal of Bioinformatics
Volume 13(1):33-40, 2012

Model and molecular docking substrate stabilization of Microsporum canis keratinase


MVK Karthik, Hanan Syed, Tridisha Goswami, Pratyoosh Shukla


Birla Institute of Technology (Deemed University), Mesra, Ranchi-835215, Jharkhand, India.




Karthik MVK, Syed H, Goswami T, Shukla P., Model and molecular docking substrate stabilization of Microsporum canis keratinase, Online J Bioinform, 13(1):33-40, 2012. Keratinophilic fungi vigorously degrade keratin. Keratinase of Microsporum canis was modeled with an accuracy RMS Z score of 1.432 using PROVE software. Molecular docking between modeled keratinases from species of keratinophilic fungi viz. Microsporum canis with different types of keratins as substrates was performed with scores of -451.89 kj/mol and -262.37 kj/mol, respectively. Arg1031 is conserved in keratinase while interacting with both keratins


Key words: Keratinophilic fungi, keratin, keratinase, Microsporum canis, molecular docking.