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OJBTM
Online Journal of Bioinformatics
Volume 13(1):33-40, 2012


Model and molecular docking substrate stabilization of Microsporum canis keratinase

 

MVK Karthik, Hanan Syed, Tridisha Goswami, Pratyoosh Shukla

 

Birla Institute of Technology (Deemed University), Mesra, Ranchi-835215, Jharkhand, India.

 

ABSTRACT

 

Karthik MVK, Syed H, Goswami T, Shukla P., Model and molecular docking substrate stabilization of Microsporum canis keratinase, Online J Bioinform, 13(1):33-40, 2012. Keratinophilic fungi vigorously degrade keratin. Keratinase of Microsporum canis was modeled with an accuracy RMS Z score of 1.432 using PROVE software. Molecular docking between modeled keratinases from species of keratinophilic fungi viz. Microsporum canis with different types of keratins as substrates was performed with scores of -451.89 kj/mol and -262.37 kj/mol, respectively. Arg1031 is conserved in keratinase while interacting with both keratins

 

Key words: Keratinophilic fungi, keratin, keratinase, Microsporum canis, molecular docking.


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