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OJBTM

Online Journal of Bioinformatics

Established 1995

ISSN  1443-2250

 

Volume 22 (3): 278-285, 2021.


In silico drug targets in S. pneumoniae by microarray

 

Wadhwa G1, Setiya K2, Imran Hazra3, Mohan T Madhan 4

 

Apex Bioinformatics Centre, Department of Biotechnology, CGO complex, Lodhi Road, New Delhi [1,2,4]. Department of Computer Science, Jamia Hamdard, New Delhi [3].

 

ABSTRACT

 

Wadhwa G, Setiya K, Hazra I, Madhan MT., In silico drug targets in S. pneumoniae by microarray, Onl J Vet Res., 22 (3): 278-285, 2021. We use Streptococcus pneumoniae microarray expression data to identify co-expressed genes with virulent ones as drug targets. We describe virulent, paralogous, co-expressed genes, corresponding proteins and putative drug targets. We extracted data from Virulence Factor Database, Stanford Microarray Data and Database of Essential Genes. For analysis, we used CLUSTER and Basic Local Alignment Search. The study was undertaken using microarray data analysed for new genes co-expressed with virulent ones. Essential but dissimilar genes to host genome were selected and we found 4508 expressed genes of which 21 clusters with 50 essential genes, 18 similar to humans and 19 to gut flora discarded to yield 13 genes putative drug targets for Streptococcus pneumoniae.

 

Keywords: clusters, k-mean clustering, drug targets.


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