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Online Journal of Bioinformatics ©
Volume 11 (1):149-155, 2009.
Designing of drug for removal of methylation from Tcf21 gene in lung cancer.
1Department of Bioinformatics, UIET,
Gupta SK, Singh A, Srivastava M, Designing of drug for removal of methylation from Tcf21 gene in lung cancer, Onl J Bioinform., 11 (1):149-155, 2009. Tcf21 is a specific tumor suppressor gene associated with lung cancer. This gene is inactivated because of CpG hypermethylation of the promoter region. Removal/inhibition of methylation could prevent metastasis. This work describes DNA-ligand docking for removal of methylation. Computational approaches were used to dock drugs with methylated DNA to remove methylation by converting 5-methyl cytosine into cytosine. The in-silico docking results showed that decitabine, a DNA binding drug, could remove methylation.
Keywords: Tcf21 gene, DNA methylation, Lung cancer, Computational drug discovery.