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OJBTM
Online Journal of Bioinformatics ©
Volume 18(2):58-67,
2017.
Premnath D, Indiraleka
M., In silico epitope for malaria protein subunit
vaccines, Onl J Bioinform.,
18(2):58-67, 2017. Antigenic
peptide epitope for a vaccine must be conserved across species and induce
protection without eliciting a host-specific inflammatory response. Drugs such
as chloroquine are of major concern as mutation of target
antigens prevent effective therapy. In vitro, PvMSP-1 protein of
plasmodium vivax is a target of naturally acquired and vaccine-induced immunity
to malaria. We suggest that antibody responses to the repertoire of variable
domains of PvMsP-1 to which subjects are continuously exposed are elicited only
after several repeated infections and may require frequent boosting, with clear
implications for the development of PvMSP-1-based subunit vaccines. We found
five peptides that could have potential for subunit vaccine. An in silico epitope for malaria protein
subunit vaccine is described.
Keywords:
antimicrobial; PvMSP-1; plasmodium vivax; epitope peptide; subunit vaccine.
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