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OJB

 

Online Journal of Bioinformatics

 

Volume 7 (2): 69-73, 2006.


 Genomic predictions for T Lymphocyte epitopes  on Plasmodium falciparum (Malaria)

 

Singh SP1, Khan F2 Mishra BN3

 

1,2,3 Department of Biotechnology, Institute of Engineering & Technology, U. P. Technical University, Sitapur Road, Lucknow-226021 (U.P.) INDIA

 

 

ABSTRACT

 

Singh SP, Khan F Mishra BN, Genomic prediction for T lymphocyte epitotes on Plasmodium falciparum (Malaria). Onl J Bioinform., 7 (2) : 69-73, 2006. A barrier to vaccination against malaria is the life cycle of Plasmodium falciparum which expresses different antigens during development. The P. falciparum genome (23 Mb) encodes more than 5300 proteins, each a potential target of protective immune responses. Because immune responses to Plasmodium are dispersed over a large number of antigens an effective vaccine may have to include immunogenic epitopes of the genome highly conserved across different strains and multi-stage life cycle.  ProPred and ProPred1 were used to predict genome/proteome promiscuous helper T lymphocytes (HTL) and cytotoxic T Lymphocytes (CTL) epitopes in P. falciparum.

 

KEY-WORDS: Malaria, Plasmodium falciparum, genomics, proteomics, subunit vaccine, T-cell, epitope, bioinformatics.


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