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OJB®
Online Journal of Bioinformatics ©
Volume 7 (2): 69-73, 2006.
Singh SP1,
Khan F2 Mishra BN3
1,2,3 Department of
Biotechnology, Institute of Engineering & Technology, U. P. Technical
University, Sitapur Road, Lucknow-226021 (U.P.) INDIA
Singh SP,
Khan F Mishra BN, Genomic prediction
for T lymphocyte epitotes on Plasmodium falciparum
(Malaria). Onl J Bioinform., 7 (2) : 69-73, 2006. A
barrier to vaccination against malaria is the life cycle of Plasmodium
falciparum which expresses different antigens during development. The P.
falciparum genome (23 Mb) encodes more than 5300 proteins, each a potential
target of protective immune responses. Because immune responses to Plasmodium are dispersed over a large
number of antigens an effective vaccine may have to include immunogenic
epitopes of the genome highly conserved across different strains and
multi-stage life cycle. ProPred and ProPred1
were used to predict genome/proteome promiscuous helper T lymphocytes (HTL) and
cytotoxic T Lymphocytes (CTL) epitopes in P. falciparum.
KEY-WORDS: Malaria, Plasmodium
falciparum, genomics, proteomics,
subunit vaccine, T-cell, epitope, bioinformatics.
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