MAIN


1996-2019.All Rights Reserved. Online Journal of Bioinformatics . You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the  before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJB publications. This article may be copied once but may not be, reproduced or  re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking: To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


OJBTM

 Online Journal of Bioinformatics  

 Volume 15 (1): 54-86, 2014.


Functional diversity of melanoma antigen proteins implicated in tumor/cancer related pathways.

 

Daniel A Achinko PhD1,3. Awino Maureiq Edith Ojwank2, Anton Dormer MD3.

1International Center of Insect Physiology and Ecology (ICIPE), Nairobi, Kenya, 2University of Nairobi, Kenya, P.O Box 30197, G.P.O, Nairobi, Kenya, 3PepVax, Inc.10411 Motor City Drive Bethesda, MD 20817, USA.

 

ABSTRACT

 

Achinko DA, Ojwank AME, Dormer A., Functional diversity of melanoma antigen proteins implicated in tumor/cancer related pathways. Onl J Bioinform., 15 (1): 54-86, 2014. Evidence showing that the functional diversity of melanoma antigen proteins (MAGE) variants and their putative interactions could favor malignancy of tumors is described. Through protein-protein interaction networks, four core proteins (HDAC1, RARA, P53 and SNW1) were identified as the foundation of all the processes governing the MAGE protein network. The involvement of these proteins in various cancer pathways implicated one of the complexes predicted within the MAGE protein network and this complex was dominantly MAGE subclass A proteins. MAGE B2 was identified among the hubbal nodes making it the most essential and lethal protein for the MAGE protein network. Involvement of MAGE proteins variants in different tumors makes them potential molecules for a common vaccine target and marker for early molecular diagnosis. Driver mutations associated with the four core proteins favoring tumor progression of MAGE proteins could be exploited through genome wide association studies (GWAS) for the development of early molecular detection kits.

 

Key Words-Melanoma antigen proteins, cancer pathways, vaccine.


 

MAIN

 

FULL-TEXT (SUBSCRIPTION OR PURCHASE TITLE $25USD)