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Online Journal of Bioinformatics©
Volume 22 (2): 32-38, 2021.
Sequence pathway analysis of Mycobacterium Tuberculosis and Leprae
Lakshmi Pillai and Usha Chouhan.
Department of Computational and Integrated Science MANIT, Bhopal
Pillai L, Chouhan U., Sequence pathway analysis of Mycobacterium Tuberculosis and Leprae, Onl J Bioinform., 22 (2): 32-38, 2021. We classify Mycobacterium Tuberculosis and Mycobacterium Leprae on carbon metabolism pathway from NCBI and Swissprot/Uniprot databank Expasy server and Biocyc.org. Comparative pathway analysis resulted in 182 pathways of M. leprae and 209 in M. tuberculosis, 28 amino acid pathways for M. leprae and 38 in M. tuberculosis. We found that M. leprae metabolizes glucose, but other carbon sources are not metabolized for energy. We found pseudogenes in M. leprae that correspond to M. tuberculosis for proteins that enable bacteria to breakdown other carbon sources such as acetate and galactose. Genes responsible for H37Rv to grow in macrophages trp D, pro C and met C are possible drug targets. The carbon metabolic pathway analysis suggests commonality between M. tuberculosis and leprae pathways for future identification of drug targets.
Keywords: Mycobacterium Tuberculosis (M.TB), M. Lepare, Pathway analysis, Fibrosis, Granuloma, Axenically.