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OJBTM
Online Journal of Bioinformatics©
Volume 22 (2): 32-38, 2021.
.
Sequence pathway analysis of Mycobacterium
Tuberculosis and Leprae
Lakshmi Pillai and Usha Chouhan.
Department of Computational and
Integrated Science MANIT, Bhopal
ABSTRACT
Pillai L, Chouhan U., Sequence
pathway analysis of Mycobacterium
Tuberculosis and Leprae, Onl J Bioinform., 22 (2): 32-38, 2021. We classify Mycobacterium Tuberculosis and Mycobacterium
Leprae on carbon metabolism pathway from NCBI and
Swissprot/Uniprot databank Expasy server and Biocyc.org. Comparative pathway analysis resulted in 182
pathways of M. leprae
and 209 in M. tuberculosis, 28 amino
acid pathways for M. leprae
and 38 in M. tuberculosis. We found that M. leprae
metabolizes glucose, but other carbon sources are not metabolized for energy. We
found pseudogenes in M. leprae that correspond
to M. tuberculosis for proteins that enable bacteria to breakdown other
carbon sources such as acetate and galactose. Genes responsible for H37Rv to
grow in macrophages trp D, pro C and met C are possible
drug targets. The carbon metabolic pathway
analysis suggests commonality between M.
tuberculosis and leprae
pathways for future identification of drug targets.
Keywords: Mycobacterium Tuberculosis
(M.TB), M. Lepare, Pathway analysis, Fibrosis, Granuloma,
Axenically.
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