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OJBTM
Online Journal of
Bioinformatics
©
Volume 14 (2): 138-145,
2013
Subtractive genomic identification of drug
targets in Leishmania Donovani and L. Infantum.
Tanima
Shree (MSc)1, Suhail
Ahmad Khan (B.Tech)2, Shivanjali
Saxena (B.Tech)3.
1Institute
of Computational Biology, Domlur Layout, Bangalore,
Karnataka, 2,3Amity University Campus, Malhaur,
Gomti Nagar Extension, Lucknow, Uttar Pradesh, India.
ABSTRACT
Shree
T, Khan SA, Saxena S., Subtractive Genomic
identification of drug targets in Leishmania Donovani and Infantum, Onl J Bioinform., 14(2):138-145,
2013. Subtractive genomics can identify genes
essential to a human parasite not present in a host to identify drug targets
against Leishmania spp. Three potential proteins in Leishmania Donovani and Infantum are described which did
not share sequence homology to human proteins when compared against
genes present in the Database of Essential Genes. Glyoxylase
II and 2-Hydroxymethyl-5-(7-methylamino-imidazol[4,5-b]pyridin-3-yl)-tetrahydro-furan-3-ol(HEMBL405920)
were identified as targets in Leishmania infantum which bind to non-conserved residues in the
human enzyme.
Keywords:
Subtractive genomics, Leishmaniasis, Virtual
screening, Kala-azar, Therapeutic targets, Sub-cellular location.
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