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Online Journal of Bioinformatics ©
Volume 14 (2): 138-145, 2013
Subtractive genomic identification of drug targets in Leishmania Donovani and L. Infantum.
Tanima Shree (MSc)1, Suhail Ahmad Khan (B.Tech)2, Shivanjali Saxena (B.Tech)3.
1Institute of Computational Biology, Domlur Layout, Bangalore, Karnataka, 2,3Amity University Campus, Malhaur, Gomti Nagar Extension, Lucknow, Uttar Pradesh, India.
Shree T, Khan SA, Saxena S., Subtractive Genomic identification of drug targets in Leishmania Donovani and Infantum, Onl J Bioinform., 14(2):138-145, 2013. Subtractive genomics can identify genes essential to a human parasite not present in a host to identify drug targets against Leishmania spp. Three potential proteins in Leishmania Donovani and Infantum are described which did not share sequence homology to human proteins when compared against genes present in the Database of Essential Genes. Glyoxylase II and 2-Hydroxymethyl-5-(7-methylamino-imidazol[4,5-b]pyridin-3-yl)-tetrahydro-furan-3-ol(HEMBL405920) were identified as targets in Leishmania infantum which bind to non-conserved residues in the human enzyme.
Keywords: Subtractive genomics, Leishmaniasis, Virtual screening, Kala-azar, Therapeutic targets, Sub-cellular location.