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OJBTM

Online Journal of Bioinformatics

 

 Volume 8 (2) : 154-164, 2007


The 3D structure of the Japanese Encephalitis helicase, using homology based molecular modelling techniques.

 

Vlachakis D, Brancale A

 

Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3XF, United Kingdom

 

 

ABSTRACT

 

Vlachakis D, Brancale A., The 3D structure of the Japanese Encephalitis helicase, using homology based molecular modelling technique, Onl J Bioinform., 8 (2) 154-164, 2007. The helicase plays a key role in the life cycle of viruses of the Flaviviridae family.  Japanese encephalitis virus is a member of this family and constitutes an important human pathogen (1). In this work, towards a structure-based design of novel anti-japanese encephalitis agents, a 3D-model of the japanese encephalitis helicase virus was produced using homology modelling techniques and the known 3D-structure of the yellow fever helicase of the Flaviviridae family as template.

 

Keywords: Homology modelling; Molecular Dynamics; Helicase; Japanese Encephalitis Virus; Flaviviridae.


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