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OJBTM
Online Journal of
Bioinformatics©
Volume
8 (2) :
154-164, 2007
The 3D structure of the
Japanese Encephalitis helicase, using homology based molecular modelling
techniques.
Vlachakis D, Brancale A
ABSTRACT
Vlachakis D, Brancale A., The 3D
structure of the Japanese Encephalitis helicase, using homology based molecular
modelling technique, Onl J Bioinform.,
8 (2) 154-164, 2007. The
helicase plays a key role in the life cycle of viruses of the Flaviviridae
family. Japanese encephalitis virus is a member of this family and
constitutes an important human pathogen (1). In this work, towards a structure-based design of
novel anti-japanese encephalitis agents, a 3D-model
of the japanese encephalitis
helicase virus was produced using homology modelling techniques and the known
3D-structure of the yellow fever helicase of the Flaviviridae family as
template.
Keywords:
Homology
modelling; Molecular Dynamics; Helicase; Japanese Encephalitis Virus; Flaviviridae.
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