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Online Journal of Bioinformatics©
Volume 8 (2) : 154-164, 2007
The 3D structure of the Japanese Encephalitis helicase, using homology based molecular modelling techniques.
Vlachakis D, Brancale A
Vlachakis D, Brancale A., The 3D structure of the Japanese Encephalitis helicase, using homology based molecular modelling technique, Onl J Bioinform., 8 (2) 154-164, 2007. The helicase plays a key role in the life cycle of viruses of the Flaviviridae family. Japanese encephalitis virus is a member of this family and constitutes an important human pathogen (1). In this work, towards a structure-based design of novel anti-japanese encephalitis agents, a 3D-model of the japanese encephalitis helicase virus was produced using homology modelling techniques and the known 3D-structure of the yellow fever helicase of the Flaviviridae family as template.
Keywords: Homology modelling; Molecular Dynamics; Helicase; Japanese Encephalitis Virus; Flaviviridae.