MAIN

©1996-2019..  All Rights Reserved. Online Journal of Bioinformatics . You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the  before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJB publications. This article may be copied once but may not be, reproduced or  re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking: To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.

OJBTM

 Online Journal of Bioinformatics © 

  Volume 16 (1): 18-28, 2015.

Characterization of mouse body insulin genes with genetic network systems

 

Zeeshan Arif1 and C.K. Verma1

 

1Department of Mathematics, Computer Applications and Bioinformatics, Maulana Azad National Institute of Technology, Bhopal, India

ABSTRACT

 

Zeeshan A, VermaCK., Characterization of mouse body insulin genes using genetic network systems, Onl J Bioinform., 16 (1): 18-28, 2015. Genetic resemblance between mouse and human makes the mouse a useful mammalian model system to study obesity and diabetes. A gene network integrating clinical traits, genetic marker and gene expression data is described. Instead of concentrating on individual genes, a systems level view of a module of genes related to body insulin is used. The model allows characterization of insulin related genes utilizing an intra-modular connectivity network with genetic concepts. A WGCNA R package for performing weighted gene co-expression network analysis was used and provides an integrative genomics method for novel insights of the relationship between gene expression, body insulin and weight.

 

Keywords: Diabetes (T2DM), Obesity, Impaired Glucose Tolerance, Modules, Intramodular connectivity.

MAIN

 

FULL-TEXT (SUBSCRIPTION OR PURCHASE TITLE $25USD)