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OJBTM

Online Journal of Bioinformatics

Established 1995

ISSN  1443-2250

 

Volume 22 (3): 286-300, 2021.


In silico T-cell epitope protective antigen for Bacillus anthracis

 

Anuraj Nayarisseri S1, Sheaza Ahmed S1, Mukesh Yadav D1, Jyoti Sahu2, Priyanka Gupta3, Rachna Chourasia2, Deepti Mittal R4

 

1In silico Research Laboratory, Eminent Biosciences, 2Dept of Biotechnology, Softvision College,Vijaynagar, Indor, 3Kalinga School of Biotechnology, Patia, Bhubaneswar, Odisha, 4Dept. of Bioinformatics, Dr. D. Y. Patil Biotechnology & Bioinformatics Institute,Tathawade, Pune, India.

 

ABSTRACT

 

Nayarisseri SA, Ahmed SS, Yadav DM, Sahu J, Gupta P, Chourasia R, Mittal RD., In silico T-cell epitope protective antigen for Bacillus anthracis, Onl J Bioinform., 22 (3): 286-300, 2021. Anthrax spores of Bacillus anthracis are resistant to inactivation persisting in soil infecting grazing animals by ingestion. Virulence depends on protective antigen, lethal and edema toxins binding to cell receptors but with biochemical components. We report in silico T-cell epitopes binding affinity HLAPred peptides that bind MHC Class I and II. We describe antigenic peptides, lipophilicity and solvency. Out of all peptides the peptide which shows all the character for further analyzed for protein peptide interaction to find the high affinity binding peptide with low energy.

 

Keywords: T-Cell Epitope, Bacillus anthracis, Protective Antigen and Lethal factor of Bacillus anthracis.


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