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Online Journal of Bioinformatics

Volume 5:132-145, 2004.

Prediction of  transcriptional regulation by Dlx and Msx homeodomain proteins.


Swarnalatha M,  Jutur PP,  Amouda V,  Mathur PP, Reddy AR


Bioinformatics Centre, Department of Biochemistry and Molecular Biology, School of Life Sciences Pondicherry University, Pondicherry - 605 014, India




Swarnalatha M,  Jutur PP,  Amouda V,  Mathur PP, Reddy AR., Prediction of transcriptional regulation by Dlx and Msx homeodomain proteins, Onl J Bioinform., 5:132-145, 2004 Homeodomain proteins are transcription factors that play a crucial role in early development in eukaryotes and regulate mechanisms involved in switching off/on specific subset of target genes. The Dlx & Msx homeoproteins are recruited to the transcriptional control regions of specific target genes via selective DNA-protein and/or protein-protein interactions and affect the activation or repression of their respective target genes. The regulation of genes during development, leading to the interactions between homeoproteins and other transcription factors probably enhances additional level of specificity.  In this paper, we have studied the role of Dlx and Msx homeoproteins in transcriptional regulation under these interactions using in silico methods, which would expand the scope of experimental data to construct novel models for transcriptional regulation.


KEYWORDS: Dlx-Msx heterodimerization, DNA-protein interaction, helix-turn-helix, homeodomains, protein- protein interaction