©1996-2019. All Rights Reserved. Online Journal of Bioinformatics . You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJB publications. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.
Online Journal of Bioinformatics ©
Volume 11 (2): 264-281, 2010
Predicted 3D structure, active site and ligand docking of serine acetyltransferase,
a drug target for Entamoeba histolytica
Subhash Mohan Agarwal* (PhD), Dhwani Raghav (M.Sc.) and Akshita Kumar (B.Tech)
Bioinformatics Division, Institute of Cytology and Preventive Oncology, Uttar Pradesh
Agarwal SM, Raghav D, Kumar A, Predicted 3D structure, active site and ligand docking of serine acetyltransferase, a drug target for Entamoeba histolytica Online J Bioinformatics. 11 (2): 264-281, 2010. Serine acetyltransferase (SATase) is part of the biosynthetic pathway of E. histolytica, an enteric parasite that causes amoebic colitis. The end product, cysteine is an important metabolite for the survival of E. Histolitica, thus SATase has become a target for drug development. A 3D-homology model of EhSATase, active site and predicted interactions between the protein and cysteine, the natural inhibitor are described herein. EhSATase was characterized by unique insertions in an a-helical conformation and an extended loop between b-strand 7 and 8, giving rise to potential significant structural differences. This structure knowledge may be useful for designing ehSATase inhibitors.
Keywords: Serine acetyltransferase; Homology modeling; Entamoeba histolytica; Docking; Amoebiasis