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Online Journal of Bioinformatics ©
Volume 18(1):19-29, 2017
Homology modeling docking for histone deacetylase 8.
Ahmad Mohammadi Moghaddas
Department of Genetics, Osmania University, Hyderabad
Moghaddas AM., Homology modeling docking for histone deacetylase8 (HDCA 8), Onl J Bioinform., 18(1):19-29, 2017. Histone Deacetylase (HDAC) enzymes oppose effects of HATs and reverse lysine acetylation which restores the positive charge of lysine. This potentially stabilizes the local chromatin architecture and is consistent with HDACs being predominantly transcriptional repressors. In this work we identified the inhibitory activity of Tubacin using a 3D structure for Histone Deacetylase 8 crystal structure with MVD software. The 3D structure was validated. The active site of Histone Deacetylase 8 was identified using CASTp server and active residues were used to generate an inhibitor. A tubacin molecule designed with Chemsketch software docked to HDAC8 active residue suggested that it could inhibit this histone.
Key words: HDCA8, Tubacin, Modeling, MVD and Docking studies.