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OJBTM

Online Journal of Bioinformatics 

Volume 18(1):19-29, 2017


Homology modeling docking for histone deacetylase 8.

 

Ahmad Mohammadi  Moghaddas

 

Department of Genetics, Osmania University, Hyderabad

 

ABSTRACT

 

Moghaddas AM., Homology modeling docking for histone deacetylase8 (HDCA 8), Onl J Bioinform., 18(1):19-29, 2017. Histone Deacetylase (HDAC) enzymes oppose effects of HATs and reverse lysine acetylation which restores the positive charge of lysine. This potentially stabilizes the local chromatin architecture and is consistent with HDACs being predominantly transcriptional repressors. In this work we identified the inhibitory activity of Tubacin using a 3D structure for Histone Deacetylase 8 crystal structure with MVD software. The 3D structure was validated. The active site of Histone Deacetylase 8 was identified using CASTp server and active residues were used to generate an inhibitor. A tubacin molecule designed with Chemsketch software docked to HDAC8 active residue suggested that it could inhibit this histone.

 

Key words: HDCA8, Tubacin, Modeling, MVD and Docking studies.


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