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OJBTM
Online Journal of Bioinformatics©
Volume 11 (1):98-102, 2009
Prediction
of 3-Dimensional
Structure
of GLI2 of Homo sapiens.
Sreekanth P, Narayan J.
Bioinformatics
Centre, Amity Institute of Biotechnology,
ABSTRACT
Sreekanth P, Narayan J., Prediction of
3-Dimensional Structure of GLI2 of Homo sapiens, Online
J Bioinformatics, 11 (1):98-102, 2009. Gli2 is a transcriptional activator, even though it is
also suggested to have a weak repressing activity. Gli2 is expressed in the interfollicular epidermis and the outer root sheath of hair
follicles in normal human skin and it is able to induce G1–S phase progression
in contact-inhibited keratinocytes which may drive tumour
development. Studies have also shown that GLI2 plays a dual role as activator
of keratinocyte proliferation and repressor of epidermal differentiation. For
the structure prediction with homology modeling, a template protein was
obtained by BLASTp and the predicted 3-D model may be
used to characterize the protein in a wet laboratory.
Keywords: Transcriptional activator,
homology modeling, Homo sapiens, 3-D model, PDB, Swiss model, predictive
model, Swiss-PdbViewer, PROCHECK, Ramachandran plot.
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