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Online Journal of Bioinformatics©
Volume 11 (1):98-102, 2009
Prediction of 3-Dimensional Structure of GLI2 of Homo sapiens.
Sreekanth P, Narayan J.
Centre, Amity Institute of Biotechnology,
Sreekanth P, Narayan J., Prediction of 3-Dimensional Structure of GLI2 of Homo sapiens, Online J Bioinformatics, 11 (1):98-102, 2009. Gli2 is a transcriptional activator, even though it is also suggested to have a weak repressing activity. Gli2 is expressed in the interfollicular epidermis and the outer root sheath of hair follicles in normal human skin and it is able to induce G1–S phase progression in contact-inhibited keratinocytes which may drive tumour development. Studies have also shown that GLI2 plays a dual role as activator of keratinocyte proliferation and repressor of epidermal differentiation. For the structure prediction with homology modeling, a template protein was obtained by BLASTp and the predicted 3-D model may be used to characterize the protein in a wet laboratory.
Keywords: Transcriptional activator, homology modeling, Homo sapiens, 3-D model, PDB, Swiss model, predictive model, Swiss-PdbViewer, PROCHECK, Ramachandran plot.