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Online Journal of Bioinformatics©
Volume 1 (19):20-24, 2018.
GC dispersion in non-coding RNAs from E.coli K12 genome.
Sridhar J, Rafi ZA
Centre of Excellence in Bioinformatics, School of Biotechnology, Madurai Kamaraj University, Madurai 625021, India.
Sridhar J, Rafi ZA., GC dispersion in non-coding RNAs from E. coli K12 genome. Onl J Bioinform 1 (19):20-24, 2018. Non-coding RNAs (ncRNAs) are primary transcripts which exert their function directly in the cell instead of coding for amino acids. The GC distribution of ncRNAs in the entire E.coli K12 genome (RNome) was analyzed. GC distribution in coding genes was illustrated with tRNA, rRNA, sRNA and intergenic regions. Results showed that 83% of sRNAs GC distribution ranged from 45% to 52%. A shift in GC content of tRNA genes decoding polar-charged (non-hydrophobic) and hydrophobic amino acids and a correlation between the GC distribution and tRNA iso-types was found. This study suggests that tRNA iso-types having low GC% may decode non-hydrophobic amino acids and high GC%, hydrophobic ones.
Key words: %GC, ncRNA, GC bias, hash value, sRNA.