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Online Journal of Bioinformatics ©
Volume 16 (2): 194-201, 2015.
Respiratory gating in lung cancer radiotherapy
Konstantina Konstantara1,2, Antonios Danelakis3, Dionisia Tzogogianni3, Eleftheria Polychronidou4,
Georgios Venieris5, Louis Papageorgiou1,3,*, Dimitrios Vlachakis1,*
1Computational Biology & Medicine Group, Biomedical Research Foundation, Academy of Athens, Soranou Efessiou, Athens, 2Department of Physics, National and Kapodistrian University of Athens, University Campus, Athens, 3Department of Informatics and Telecommunications, National and Kapodistrian University of Athens, University Campus, Athens, 4Department of Informatics, Ionian University, Tsirigoti Square, Corfu, 5Nuclear Medicine Department, Diagnosis, 166 Alexandras Avenue, Ampelokipoi, Athens, Greece.
KonstantaraK, Danelakis A, Tzogogianni D, Polychronidou E, Venieris G, Papageorgiou L, Vlachakis D., Respiratory gating for lung cancer radiotherapy, Onl J Bioinform., 16 (2): 194-201, 2015. For chest and abdominal cancer radiotherapy accuracy, respiratory motion needs to be visualized, controlled, and tracked. Even though respiratory gating reduces motion artifacts, it is expensive and frequently, respiratory correlated dynamic (RCD) positron emission tomography (PET), is used instead. This technique permits acquirement of 4-dimensional PET data without a respiratory tracking device and does not require patient compliance as it is not susceptible to irregular breathing. RCDPET also gives the ability to reconstruct images from any breathing phase of the exam, vital for both diagnosis and treatment. We describe an analytical approach for lung cancer radiotherapy using respiratory gating and RCDPET. Deep-inspiration breath-hold and free-breath to reduce respiratory effects were compared.
Key-Words: Cancer, radiotherapy, Respiratory gating.