Respiratory gating in lung cancer radiotherapy

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OJBTM

Online Journal of Bioinformatics ©

Volume 16 (2): 194-201, 2015.

Respiratory gating in lung cancer radiotherapy

Konstantina Konstantara^1,2, Antonios Danelakis³, Dionisia Tzogogianni³, Eleftheria Polychronidou⁴,

Georgios Venieris⁵, Louis Papageorgiou^1,3,*, Dimitrios Vlachakis^1,*

¹Computational Biology & Medicine Group, Biomedical Research Foundation, Academy of Athens, Soranou Efessiou, Athens, ²Department of Physics, National and Kapodistrian University of Athens, University Campus, Athens, ³Department of Informatics and Telecommunications, National and Kapodistrian University of Athens, University Campus, Athens, ⁴Department of Informatics, Ionian University, Tsirigoti Square, Corfu, ⁵Nuclear Medicine Department, Diagnosis, 166 Alexandras Avenue, Ampelokipoi, Athens, Greece.

ABSTRACT

KonstantaraK, Danelakis A, Tzogogianni D, Polychronidou E, Venieris G, Papageorgiou L, Vlachakis D., Respiratory gating for lung cancer radiotherapy, Onl J Bioinform., 16 (2): 194-201, 2015. For chest and abdominal cancer radiotherapy accuracy, respiratory motion needs to be visualized, controlled, and tracked. Even though respiratory gating reduces motion artifacts, it is expensive and frequently, respiratory correlated dynamic (RCD) positron emission tomography (PET), is used instead. This technique permits acquirement of 4-dimensional PET data without a respiratory tracking device and does not require patient compliance as it is not susceptible to irregular breathing. RCDPET also gives the ability to reconstruct images from any breathing phase of the exam, vital for both diagnosis and treatment. We describe an analytical approach for lung cancer radiotherapy using respiratory gating and RCDPET. Deep-inspiration breath-hold and free-breath to reduce respiratory effects were compared.

Key-Words: Cancer, radiotherapy, Respiratory gating.

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