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Onl J Bioinform©
Established 1995
ISSN 1443-2250
Volume 25 (1) : 49-59,
2024.
Predicting
T lymphocyte epitopes on Plasmodium
falciparum.
Singh SP, Khan F, Mishra BN.
Department
of Biotechnology, Institute of
Engineering & Technology, U. P. Technical University, Sitapur
Road, Lucknow India.
Singh SP, Khan F Mishra BN Genomic prediction for T lymphocyte
epitopes on Plasmodium falciparum (Malaria). Onl J Bioinform, 25 (1) : 49-59, 2024. Plasmodium
falciparum expresses different antigens during development with a 23 Mb genome
that encodes ~>5300 proteins, targets for immune response. Because immune
responses to Plasmodium are dispersed
over a large number of antigens, effective vaccine must include highly
conserved epitopes. ProPred
and ProPred1 were used to predict genome/proteome promiscuous helper T
lymphocytes (HTL) and cytotoxic T Lymphocytes (CTL) epitopes in P. falciparum.
KEY-WORDS:
Malaria, Plasmodium falciparum,
genomics, proteomics, subunit vaccine, T-cell, epitope, bioinformatics.
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