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OJBTM
Online Journal of Bioinformatics©
Volume 21 (3):288-300, 2020.
Dopamine receptor D1A phylogenetic relationship
amongst different organisms.
Prashant
Shukla, PhD,
Assistant Professor,
Department of Biotechnology, School of Life Sciences, The Neotia
University, Kolkata, West Bengal, India, 8719024461
Abstract
Shukla P., Dopamine receptor d1a
phylogenetic relationship amongst different organisms, Onl
J Bioinform, 21 (3):288-300, 2020. Cell to cell communication by signal transduction proteins is essential
for cell survival. Author describes phylogeny
of dopamine receptor D1A from public databases in animals, primates, apes and humans.
The dopamine receptor D1A phylogenetic tree revealed expected branches of old separate
from new world primates. Phylogenetic analysis of dopamine receptor D1A of 50
animals, 6 apes and humans showed similar branching. The dopamine receptor D1A
of gorilla was closest to human while chimpanzee and bonobo were similar but
further from human and gorilla, Orangutan and gibbon produced separate branches.
The tentative groups formed in the phylogenetic analysis were similar to
previous findings but dopamine receptors genes in humans
revealed receptors D1A and D5 and proteins D2, D3 and D4 to form two dopamine families.
Different motif locations in similar organisms suggested that D1A amino acid
sequences differed even though gene function remained similar.
Keywords:
Dopamine receptor, phylogenetic analysis, proteins, cell
communication, signal transduction.
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