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Online Journal of Bioinformatics ©
Volume 12(1):198-206, 2011
Computational analysis of diversity coding for 3-KetoAcyl-Co A synthase 20 for fatty acid elongation pathway in plants.
Monendra Grover* and Satbir Kaur
National Bureau of Plant Genetic Resources, Pusa Campus, New Delhi , India
Grover M, Kaur S., Computational analysis of diversity coding for 3-KetoAcyl-Co A synthase 20 for fatty acid elongation pathway in plants, Online J Bioinformatics, 12(1):198-206, 2011. Genetic diversity in the homologs of Arabidopsis KCS20 gene (AT5G43760) coding for 3-ketoacyl-coA synthase 20 of fatty acid elongation pathway in selected plants is described. There were similarities in KCS 20 proteins in the total number of negative and positive charged residues, extinction coefficients, estimated half-lifes, instability indexes, and domain and secondary structure organization. However, there were notable differences in number of exons, predicted O-Glycosylated residues, number of O-GlcNAc, predicted sumoylation and kinase specific phosphorylation sites, residues contributing to nuclear export signal and transmembrane helices. The differences described may affect the quantitative efficiency of 3-keto-acylcoA synthase to catalyze condensation of c2 units to acyl coA during fatty acid elongation. This paper showcases genetic diversity in KCS 20 gene and its molecular implications which could be used to create a diverse genetic base for engineering KCS 20 genes.
Keywords: Fatty acids, genetic diversity, metabolic engineering; List of Abbreviations: VLCFA: Very Long Chain Fatty acids, KCS: Keto-acyl-synthase