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OJBTM
Online
Journal of Bioinformatics©
Established 1995
ISSN 1443-2250
Volume 23 (1): 30-36, 2022
In
silico curcumin binding with human papilloma virus 16 E6 protein
Ajay Kumar Singh
and Krishna Misra
Centre For Biomedical Magnetic Resonance, SGPGI campus, Lucknow.
ABSTRACT
Singh AK, Misra K., In
silico curcumin binding with human papilloma virus 16 E6 protein, Onl J Bioinform., 23 (1): 30-36, 2022. Curcumin (diferuloyl
methane) and its naturally occurring analogs viz. demethoxy,
bis-demethoxy and cyclo-curcumin,
present in the rhizomes of Curcuma species (turmeric) have been shown to
inhibit the proliferation of a wide variety of tumor cells. In silico studies
indicate that these have super binding with different active sites on HPV E6
protein, an ideal target for restoring the tumor suppressor function of p53 and
thus allowing the apoptosis of infected cells. Target nuclear protein HPV E6
(PDB i.d. 2fk4) is 158 amino acids long, and is the
major protein actively participating in oral and cervical cancers. Therefore,
these herbal lead compounds can form the basis for potent, non-toxic drugs for
oral and cervical cancers.
KEY WORDS: HPV
(Human Papilloma virus), OC (oral cavity), PDB (Protein Data Bank).
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