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Online Journal of Bioinformatics©
Volume 23 (1): 30-36, 2022
In silico curcumin binding with human papilloma virus 16 E6 protein
Ajay Kumar Singh and Krishna Misra
Centre For Biomedical Magnetic Resonance, SGPGI campus, Lucknow.
Singh AK, Misra K., In silico curcumin binding with human papilloma virus 16 E6 protein, Onl J Bioinform., 23 (1): 30-36, 2022. Curcumin (diferuloyl methane) and its naturally occurring analogs viz. demethoxy, bis-demethoxy and cyclo-curcumin, present in the rhizomes of Curcuma species (turmeric) have been shown to inhibit the proliferation of a wide variety of tumor cells. In silico studies indicate that these have super binding with different active sites on HPV E6 protein, an ideal target for restoring the tumor suppressor function of p53 and thus allowing the apoptosis of infected cells. Target nuclear protein HPV E6 (PDB i.d. 2fk4) is 158 amino acids long, and is the major protein actively participating in oral and cervical cancers. Therefore, these herbal lead compounds can form the basis for potent, non-toxic drugs for oral and cervical cancers.
KEY WORDS: HPV (Human Papilloma virus), OC (oral cavity), PDB (Protein Data Bank).