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OJBTM
Online
Journal of Bioinformatics©
Volume 9 (1): 12-20, 2008.
Elucidating the role of
CREBBP co-activator in erythroid differentiation by literature mining and
analysis.
Iyer J1*, Raghunath A1, Bhate J1 and Wong.L2
1 Molecular Connections Pvt. Ltd, Kandala
Mansions, #2/2 Kariappa Road (South Cross Road), Basavanagudi, Bangalore – 560004, India and 2National
Institute of Singapore, Science Drive 2,
Singapore 117543, Republic of Singapore
ABSTRACT
Iyer J, Raghunath A, Bhate J, Wong L., Elucidating the role of CREBBP
co-activator in erythroid differentiation by literature mining and analysis, Onl J Bioinform.,
9 (1): 12-20, 2008. Differentiation
of pluripotent hematopoietic stem cells into mature circulating erythrocytes
are coordinated by a set of lineage- and tissue specific transcription
factors. The two highly related nuclear proteins CREB binding protein (CBP or
CREBBP) and p300 are co-activators that possess histone acetyltransferase
activity, play a central role in the integration of transcription signals
involving diverse cellular processes and differentiation pathways such as
hematopoiesis, embryogenesis and so .We have been
using literature mining successfully to unravel various biological processes
and provide a concise view of regulation of the physiological networks. An
interaction database NetProTM was used as
a source of all interactions in this study. By further network analysis, CBP is
shown as a molecular integrator of hematopoietic differentiation. Several
transcription factor nodes through which the master regulatory cofactor CBP
binds and modulates the expression or activity of downstream genes involved in
erythrocyte differentiation have been elucidated.
Key words: CBP, CREBBP, erythrocyte
differentiation, transcription factor network, literature mining
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