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Online Journal of Bioinformatics©
Volume 9 (1): 12-20, 2008.
Elucidating the role of CREBBP co-activator in erythroid differentiation by literature mining and analysis.
Iyer J1*, Raghunath A1, Bhate J1 and Wong.L2
1 Molecular Connections Pvt. Ltd, Kandala Mansions, #2/2 Kariappa Road (South Cross Road), Basavanagudi, Bangalore – 560004, India and 2National Institute of Singapore, Science Drive 2, Singapore 117543, Republic of Singapore
Iyer J, Raghunath A, Bhate J, Wong L., Elucidating the role of CREBBP co-activator in erythroid differentiation by literature mining and analysis, Onl J Bioinform., 9 (1): 12-20, 2008. Differentiation of pluripotent hematopoietic stem cells into mature circulating erythrocytes are coordinated by a set of lineage- and tissue specific transcription factors. The two highly related nuclear proteins CREB binding protein (CBP or CREBBP) and p300 are co-activators that possess histone acetyltransferase activity, play a central role in the integration of transcription signals involving diverse cellular processes and differentiation pathways such as hematopoiesis, embryogenesis and so .We have been using literature mining successfully to unravel various biological processes and provide a concise view of regulation of the physiological networks. An interaction database NetProTM was used as a source of all interactions in this study. By further network analysis, CBP is shown as a molecular integrator of hematopoietic differentiation. Several transcription factor nodes through which the master regulatory cofactor CBP binds and modulates the expression or activity of downstream genes involved in erythrocyte differentiation have been elucidated.
Key words: CBP, CREBBP, erythrocyte differentiation, transcription factor network, literature mining