©1996-2013 All Rights Reserved. Online Journal of Bioinformatics . You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned, must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJB publications. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.
Online Journal of Bioinformatics ©
Volume 14 (2): 104-117, 2013
In silico gene prediction for autosomal recessive cone-rod dystrophy 8 (CORD8).
Naureen Aslam Khattak¹*, Sobiah Rauf2, Sheikh Arslan Sehgal2, Dure Shahwar1 and Muhammad Ismail3
1Department of Biochemistry, PMAS-Arid Agriculture University, Rawalpindi, 2 Department of Bioinformatics and Biotechnology, DES, International Islamic University, Sector H-10, Islamabad, , 3Institute of Biomedical and Genetic Engineering, (IBGE), 24 Mauve Area, G-9/1, Islamabad, Pakistan.
Khattak NA, Rauf S, Sehgal SA, Shahwar D and Ismail M., In silico gene prediction for autosomal recessive cone-rod dystrophy 8 (CORD8), Onl J Bioinform., 14 (2): 104-117, 2013. Autosomal recessive cone-rod dystrophy 8 (CORD8) genes in 1q23-q24 chromosomal interval between markers D1S1653 and D1S403, were determined using FGENESH, GeneMark.hmm, Genscan (eukaryotes) and Augustus. The analysis suggested that DNA Contigs, AL663023, AL513208, AL035403, AL513307 and AL136457 not yet mapped in 1q23-q24 between physical coordinates 157932671 bp to 163727618 bp (UCSC Genome Browser. 2009, GRCh37/hg19), may be involved in autosomal cone rod dystrophy. These potential genes could assist in understanding the pathogenesis of CORD8. Comparative modeling predicted the 3-dimensional structure of novel genes in DNA contigs AL663023 and AL136457.
Key Words: Computational Molecular biology, Gene finding, Gene searching, CORD8 , Genetic mapping, Comparative modeling,